The synthesis and antitumor evaluation of unsymmetrical bis-imides

Autor:	Patten Arthur David, R. J. Page, Margaret P. Stafford, R. J. Mcripley, M. R. Kirshenbaum, P. M. Czerniak, Robert J. Cherney, E. Akamike, Robert F. Kaltenbach, Mike Vavala, Zelleka Getahun, Steven P. Seitz, George L. Trainor, Stephen G. Swartz, Janet L. Gross, L. M. Papp, R. J. Diamond, Jung-Hui Sun, Carl Henry Behrens
Rok vydání:	1997
Předmět:	Antitumor activity Stereochemistry Ratón Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Chemical synthesis Combinatorial chemistry In vitro Human tumor chemistry.chemical_compound chemistry In vivo Drug Discovery Molecular Medicine Imide Molecular Biology DNA
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 7:163-168
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(96)00591-4
Popis:	Unsymmetrical bis-imides 1 were synthesized and evaluated as potential antitumor agents. These novel bis-imides were assessed using three criteria: in vitro cytotoxicity (L1210), in vitro DNA binding, and in vivo studies with human tumor xenografts in mice. These studies identified DMP 315 as a potent, water soluble antitumor agent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aaeac0370b60b43a7b682aae544d033d https://doi.org/10.1016/s0960-894x(96)00591-4 Zobrazit plný text záznamu Full Text from ScienceDirect