Synthesis and characterization of the environmental-sensitive hyperbranched polymers as novel carriers for controlled drug release
| Autor: | Zhong‐Lin Cao, Wei‐Xing Cheng, Yuyang Liu, Hui Hu, Xiaodong Fan |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
chemistry.chemical_classification
Materials science Polymers and Plastics Atom-transfer radical-polymerization General Chemistry Polymer Branching (polymer chemistry) Methacrylate Surfaces Coatings and Films Styrene chemistry.chemical_compound chemistry Polymer chemistry Materials Chemistry Molecule Drug carrier Macromolecule |
| Zdroj: | Journal of Applied Polymer Science. 101:311-316 |
| ISSN: | 1097-4628 0021-8995 |
| DOI: | 10.1002/app.23469 |
| Popis: | Novel hyperbranched polymers, which contain a hydrophobic branched poly(p-(chloromethy)styrene) (PCMS) core and poly(N,N-dimethylaminoethyl methacrylate) (PDMA) shell that exhibited environmental sensitivity, have been synthesized by atom transfer radical polymerization (ATRP). At first, a hyperbranched polymer (PCMS) core is obtained via ATRP of p-(chloromethy)styrene (CMS), which may act as an “inimer”-monomer and initiator. Then the modified hyperbranched polymers having different average arm length consisting of PCMS and PDMA are synthesized by ATRP using anterior PCMS as macroinitiators. Their macromolecular structures are characterized by FTIR and 1H NMR. Using chlorambucil as a model drug, the behaviors of the controlled drug release from the environmental-sensitive hyperbranched polymers with different average chain length of PDMA and degree of branching are studied. The data demonstrate that the rate of the drug release can be effectively controlled by pH value, and these environmental-sensitive hyperbranched polymers have the potential to be used as novel carriers in some controlled drug release systems in the future. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 101: 311–316, 2006 |
| Databáze: | OpenAIRE |
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