A Controlled Safety Study of Elevated Dosages of Trimethoprim Plus Sulfadiazine in Mature Horses

Autor:	Robbin Koenig, Peggy Anne Hawkins, Craig Reinemeyer
Rok vydání:	2014
Předmět:	medicine.medical_specialty Dose Equine business.industry Horse bacterial infections and mycoses Gastroenterology Trimethoprim Surgery Loose feces Sulfadiazine Internal medicine medicine Adverse effect business medicine.drug
Zdroj:	Journal of Equine Veterinary Science. 34:626-631
ISSN:	0737-0806
DOI:	10.1016/j.jevs.2013.12.001
Popis:	A novel, proprietary, oral suspension of trimethoprim plus sulfadiazine (TMP/SDZ) had no serious adverse effects on clinical, laboratory, or pathologic parameters of mature horses when administered at up to five times the intended combined dosage of 24 mg/kg twice daily for 30 consecutive days. Loose feces was the most common observation that was likely related to TMP/SDZ treatment, and the incidence of loose feces was greater in groups treated with higher dosages of TMP/SDZ. However, all episodes were self-limiting, and no horses were treated for loose feces.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aae394d7c7dc2197bfdd65f97262339d https://doi.org/10.1016/j.jevs.2013.12.001 Zobrazit plný text záznamu Full Text from ScienceDirect