Non-human primate models of multiple sclerosis
| Autor: | Margreet Jonker, Sandra Amor, Herbert P.M. Brok, Erwin L. A. Blezer, R. E. Bontrop, Jon D. Laman, Bert A. 't Hart, Jan Bauer |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
education.field_of_study
Multiple sclerosis Immunology Population Biology medicine.disease biology.organism_classification medicine.disease_cause Callithrix Myelin oligodendrocyte glycoprotein Autoimmunity Immune system Demyelinating disease medicine biology.protein Immunology and Allergy Experimental pathology education Neuroscience |
| Zdroj: | Immunological Reviews. 183:173-185 |
| ISSN: | 0105-2896 |
| DOI: | 10.1034/j.1600-065x.2001.1830114.x |
| Popis: | The phylogenetic proximity between non-human primate species and humans is reflected by a high degree of immunological similarity. Non-human primates therefore provide important experimental models for disorders in the human population that are caused by the immune system, such as autoimmune diseases. In this paper we describe non-human primate models of multiple sclerosis, a chronic inflammatory and demyelinating disease of the human central nervous system. While reviewing data from the literature and our own research we will discuss the unique role of such models in the research of basic disease mechanisms and the development of new therapies. |
| Databáze: | OpenAIRE |
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