Antioxidant Role of Carvacrol Against Hepatotoxicity and Nephrotoxicity Induced by Propiconazole in Rats
| Autor: | Rehab A. Azouz, Abdel Azeim A. Khalaf, Marwa A. Ibrahim, Asmaa A. Azouz, Eman I. Hassanen, Mona K. Galal, Mohamed A. Elhady, Peter A. Noshy |
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| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
010405 organic chemistry business.industry medicine.medical_treatment Pharmacology Malondialdehyde medicine.disease_cause 01 natural sciences 0104 chemical sciences Nephrotoxicity Propiconazole Lipid peroxidation 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Toxicity medicine Carvacrol General Pharmacology Toxicology and Pharmaceutics business Oxidative stress |
| Zdroj: | Revista Brasileira de Farmacognosia. 31:67-74 |
| ISSN: | 1981-528X |
| DOI: | 10.1007/s43450-021-00127-8 |
| Popis: | Propiconazole is a broadly used fungicide that leaves residues in food and water causing severe dangerous effects on humans and animals. The current investigation was performed to evaluate the propiconazole toxicity on the liver and kidney of male albino rats and to assess the protective role of carvacrol against these adverse effects. Sixty male Wistar albino rats were used in this experiment and were divided into four equal groups: control group, propiconazole group, carvacrol group, and propiconazole + carvacrol group. Rats were treated daily by oral gavage for 60 days with propiconazole (75 mg/kg) and/or carvacrol (50 mg/kg). The results demonstrated that exposure to propiconazole resulted in a significant elevation in serum biomarkers that indicate malfunction of the liver and kidney. Additionally, exposure to propiconazole resulted in oxidative stress and lipid peroxidation manifested by a significant reduction in glutathione content and catalase activity, and a significant increase in malondialdehyde content in the liver and kidney. These toxic effects were confirmed by histopathological studies and DNA laddering assay. Conversely, carvacrol reduced propiconazole-induced detrimental effects and improved the histopathological pictures of both liver and kidney tissues. Therefore, carvacrol can be used as a prophylactic natural compound against propiconazole-induced toxic effects in the liver and kidney. |
| Databáze: | OpenAIRE |
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