Cytosine Arabinoside Release from Polymeric Matrices

Autor:	Bhaskar Chaudhuri, Alisa E. Goetz
Rok vydání:	1989
Předmět:	Pharmacology chemistry.chemical_classification Organic Chemistry Deamination Polymeric matrix Cancer therapy Pharmaceutical Science Myeloid leukemia Polymer Polyether polyurethane chemistry.chemical_compound chemistry Drug Discovery Copolymer Organic chemistry Cytosine Nuclear chemistry
Zdroj:	Drug Development and Industrial Pharmacy. 15:1353-1364
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639048909062750
Popis:	Cytosine arabinoside (Ara-C) has been used in the treatment of acute myeloid leukemia. However, rapid deamination reduces its effectiveness. Polymeric matrices containing ara-C were prepared in polyether polyurethane copolymer to form a protective, supply of ara-C. Release studies from these devices showed linear relationships between Q, the amount release per unit area, versus the square root of time. Burst effects were predominant at higher loading doses. The diffusivity values indicated that enough drug could pass through the polymer for the combination to have potential application as implants in cancer therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aacbc1c42afa9dfc052928624f70a3dd https://doi.org/10.3109/03639048909062750 Zobrazit plný text záznamu