Low-molecular weight peptides isolated from seahorse (Hippocampus abdominalis) improve vasodilation via inhibition of angiotensin-converting enzyme in vivo and in vitro
| Autor: | Lei Wang, Hyun-Soo Kim, Hyo-Geun Lee, Yu-An Lu, Jun-Geon Je, Jae-Young Oh, Sum Rho, You-Jin Jeon |
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| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
animal structures biology Chemistry chemical and pharmacologic phenomena hemic and immune systems Bioengineering Vasodilation Angiotensin-converting enzyme Pharmacology biology.organism_classification Applied Microbiology and Biotechnology Biochemistry In vitro Hydrolysate Ultrafiltration (renal) Enzyme In vivo Seahorse embryonic structures biology.protein biological phenomena cell phenomena and immunity |
| Zdroj: | Process Biochemistry. 95:30-35 |
| ISSN: | 1359-5113 |
| DOI: | 10.1016/j.procbio.2020.04.016 |
| Popis: | According to relevant literature, the consumption of seahorses has been used to increase male functions by improving blood flow and decreasing blood pressure. Thus, it was theorized that seahorses may also be effective against hypertension. Herein, vasodilation caused via the inhibitory effect of angiotensin-converting enzymes (ACEs) in peptides was elucidated by studying the seahorses (Hippocampus abdominalis) farmed at Jeju in South Korea. Hydrolysate was prepared using the Protamex (SHP) enzyme. The ultrafiltration system was adopted to separate certain fractions from SHP according to different molecular weights (SHP-I, MW > 10 kDa; SHP-II, MW = 5−10 kDa; SHP-III, MW |
| Databáze: | OpenAIRE |
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