A Single-Center Randomized Controlled Trial of Local Methylcobalamin Injection for Subacute Herpetic Neuralgia
| Autor: | Yan Feng, Zhongwei Lv, Gang Xu, Gang Xiao Xu, Wei-Zhen Tang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Lidocaine business.industry General Medicine Single Center medicine.disease Rash Surgery law.invention Subcutaneous injection Anesthesiology and Pain Medicine Allodynia Randomized controlled trial law Anesthesia Methylcobalamin medicine Neuralgia Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Pain Medicine. 14:884-894 |
| ISSN: | 1526-2375 |
| Popis: | Objective This study explored the efficacy of local methylcobalamin injection in relieving pain and improving the quality of life among subjects with subacute herpetic neuralgia. Design A single-center, randomized controlled trial of local methylcobalamin injection was performed. Subjects Ninety-eight subjects (age, ≥50 years) with unilateral, dermatomal pain ≥4 related to herpes zoster on the torso lasting for 30 days after onset of rash were enrolled. Methods Subjects were randomized to receive local methylcobalamin injection (N = 33), oral methylcobalamin (N = 33), or subcutaneous 1.0% lidocaine injection (N = 32) for 4 weeks. Worst pain severity, global impression of change, continuous spontaneous pain, paroxysmal pain, allodynia, paresthesia, interference with activities of daily living, and quality of life were assessed after 28-day treatment period. Results Time per group interaction and group difference on overall pain at each follow-up point were statistically significant (P 0.05). Conclusions Local methylcobalamin injection was not only efficacious in relieving pain, but also appears to be tolerable and a potential choice of treatment for subacute herpetic neuralgia. |
| Databáze: | OpenAIRE |
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