Evaluation of Pexion ® (imepitoin) for treatment of storm anxiety in dogs: A randomised, double‐blind, placebo‐controlled trial

Autor: Carrie Emke, Emily H. Griffith, Margaret E. Gruen, P. Watson, Brianna Johnson, Irina Perdew, Vaidehi Dixit, Yukun Song
Rok vydání: 2021
Předmět:
Zdroj: Veterinary Record. 188
ISSN: 2042-7670
0042-4900
Popis: BACKGROUND While often grouped with other noise aversions, fearful behaviour during storms is considered more complex than noise aversion alone. The objective here was to assess the effect of imepitoin for the treatment of storm anxiety in dogs. METHODS In this double-blind, placebo-controlled randomised study, eligible dogs completed a baseline then were randomised to receive either imepitoin (n = 30; 30 mg/kg BID) or placebo (n = 15) for 28 days. During storms, owners rated their dog's intensity for 16 behaviours using a Likert scale. Weekly, owners rated intensity and frequency of these behaviours. Summary scores were compared to baseline and between groups. RESULTS AND CONCLUSIONS Imepitoin was significantly superior to placebo in storm logs and weekly surveys for weeks 2 and 4, and in the end-of-study survey. Mild/moderate adverse events were reported in 26 patients (24 active: two placebo); the most frequent adverse event was ataxia. Owners of dogs in the imepitoin group, compared to placebo, were significantly more likely to report that treatment reduced their dogs fear and anxiety during storms (p
Databáze: OpenAIRE
Externí odkaz: