Enantioselective synthesis of dihydroquinazolinone derivatives catalyzed by a chiral organocatalyst

Autor:	Veeramanoharan Ashokkumar, Siva Ayyanar, Sankar Balakrishnan, Ponmuthu Kottala Vijaya, Sepperumal Murugesan, Velu Sadhasivam, Chithiraikumar Chinnadurai, Madhappan Mariyappan
Rok vydání:	2017
Předmět:	010405 organic chemistry Chemistry Materials Chemistry Enantioselective synthesis Organic chemistry Amine gas treating General Chemistry Enantiomer 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences
Zdroj:	New Journal of Chemistry. 41:7980-7986
ISSN:	1369-9261 1144-0546
DOI:	10.1039/c7nj00538e
Popis:	The asymmetric condensation/amine addition cascade sequence of 2-aminobenzamide and aldehydes, catalyzed by a novel chiral organocatalyst, was realized. The organocatalyst was found to be very effective and highly enantioselective for such cascade reactions at room temperature, affording 2,3-dihydroquinazolinones in excellent yields (up to 99%) with enantiomeric excesses of up to 97%. The best level of stereocontrol was obtained for aromatic/aliphatic aldehydes with ortho, para or meta substituents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aaaab7f7af6cf8776fbb9df45d39d119 https://doi.org/10.1039/c7nj00538e Zobrazit plný text záznamu