Effect of oxidative stress markers in breast carcinoma patients
| Autor: | Nethala Ravi Kumar, Abhay John, Md Masood Ahmed Shareef, Siddharth D. Pimpalkar |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International journal of health sciences. :10116-10126 |
| ISSN: | 2550-696X 2550-6978 |
| DOI: | 10.53730/ijhs.v6ns6.12727 |
| Popis: | Background: Curiosity in view of the literature regarding breast cancer especially in our country, there has been little study on breast cancer individuals during and progression of the cancer on oxidative stress markers. Aim: To determine the effect of MDA, TAC, SOD, Catalase, reduced glutathione in breast cancer subjects and to compare them with the apparently healthy controls. Methods: Lately diagnosed female subjects with breast cancer in the age group of 40-60 years were included in the study. Apparently healthy controls were selected from the group of people who were attending for annual health check-up and found to be healthy. Results: On comparison between the two groups, the present study observed significant differences in the values of MDA, TAC, and reduced glutathione. Interestingly, we observed higher levels of MDA in the subjects suffering with breast carcinoma, whereas lower levels in the apparently healthy controls incorporated in the study. Comparing between the groups of LDL and HDL level, the present study observed significant difference. Conclusion: The present study concludes that alterations in the study parameters in breast cancer group are due to dys-balance oxidants production and lower expression of antioxidants. |
| Databáze: | OpenAIRE |
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