| Autor: |
Xu-gang Hu, De-min Jiao, You-liang Si, Jun Chen, Xia-li Tang, Da-wei Wang, Qing-yong Chen |
| Rok vydání: |
2019 |
| DOI: |
10.21203/rs.2.16162/v1 |
| Popis: |
Background: Tobacco exposure is the most important risk factor for the occurrence and death of lung cancer. Fibrinogen beta chain (FGB), the most abundant coagulation factor in plasma, is putatively involved in tumor progression. This study aimed to evaluate the expression pattern and prognostic value of FGB in lung adenocarcinoma with tobacco exposure. Methods: FGB expression in lung adenocarcinoma (LUAD) and corresponding normal lung tissues was compared in The Cancer Genome Atlas (TCGA) database. Stratified analysis was conducted to investigate the expression of FGB in LUAD patients with different tobacco exposure. Kaplan-Meier analysis and Cox-regression analysis were performed to evaluate the prognostic significance of FGB. The same survival analyses were conducted in the KM plotter database to validate the prognostic value of FGB. Results: FGB expression was significantly increased in LUAD tissues than in normal tissues (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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