Placental Vascular Malformation with Mesenchymal Hyperplasia and a Localized Chorioangioma
| Autor: | K.-E. Højberg, Lone Sunde, J. Aagaard, U. Henriques |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Fetus
Pathology medicine.medical_specialty Vascular malformation Mesenchymal stem cell Ground substance Chorionic vessels Cell Biology Anatomy Biology Hyperplasia medicine.disease Placental Mesenchymal Dysplasia Pathology and Forensic Medicine medicine.anatomical_structure Placenta embryonic structures medicine |
| Zdroj: | Pathology - Research and Practice. 190:808-813 |
| ISSN: | 0344-0338 |
| DOI: | 10.1016/s0344-0338(11)80429-2 |
| Popis: | Summary We here report a case o f placental vascular malformation with mesenchymal hyperplasiaof the villi and a localized chorioangioma. After an uneventful pregnancy our patient delivered a non-malformed live femaleinfant. The placenta was grossly enlarged, and macroscopically it was characterized by strongly enlarged varicous chorionic vessels. On the maternal plate vesicle-like structures, giving the impression o f partial mole, were seen. At microscopy level, areas of normal looking tissue alternated with areas of excessivelyenlarged villi, in which the ground substance contained large amounts of acid mucopolysaccharide, corresponding to “mesenchymal hyperplasia”. Moreover, a localized chorioangioma was found. In none of the histological sections were cisterns, abnormal trophoblastic proliferation, stunted ramification or stromal trophoblastic inclusions observed. In week 15 maternal se-AFP was elevated to 3.03 multiples o f the median. Geneticanalyses revealed a normal female karyotype and biparental genomic contributions to 7 unlinked loci. Placental vascular malformation with mesenchymal hyperplasia is a differential diagnosis to partial mole which should be considered when vesicle like placental enlargement is observed along with a living fetus. |
| Databáze: | OpenAIRE |
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