Spectrum of gallbladder malignancies on fine-needle aspiration cytology: 5 years retrospective single institutional study with emphasis on uncommon variants
| Autor: | Pranab Dey, Naveen Kalra, Rajesh Kumar, Raje Nijhawan, Radhika Srinivasan, Arvind Rajwanshi, Nalini Gupta, Anupam Lal |
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| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Histology business.industry Adenosquamous carcinoma Gallbladder General Medicine medicine.disease Malignancy Giemsa stain Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Small cell neuroendocrine carcinoma medicine.anatomical_structure 030220 oncology & carcinogenesis Cytology Carcinoma Medicine Adenocarcinoma 030211 gastroenterology & hepatology business |
| Zdroj: | Diagnostic Cytopathology. 45:36-42 |
| ISSN: | 8755-1039 |
| DOI: | 10.1002/dc.23636 |
| Popis: | Background Ultrasound-guided fine-needle aspiration cytology (FNAC) is the standard modality for diagnosis of gallbladder malignant neoplasms. Adenocarcinoma is the most common malignancy; however, other types may also be encountered. The aim of this study was to perform a retrospective analysis of gallbladder malignancies diagnosed on FNAC in the last 5 years to document the cytomorphological spectrum and the variations thereof. Methods The records of the Department of Cytology, PGIMER were searched from July 2010 to June 2015 and all cases of gallbladder malignancies were analyzed in detail for cytomorphological characteristics. Giemsa and Hematoxylin−Eosin stained slides were evaluated with immunocytochemistry on cell blocks wherever available. Results A total of 791 gallbladder FNAC performed in cases of radiologically suspected gallbladder malignancies were evaluated. Gallbladder carcinoma (GBC) was more common in females with a male to female ratio of 1:2.3. Median age was 53.4 years (range 24-85 years); 81 cases (10.2%) were nondiagnostic and 31 (3.9%) were suspicious of malignancy. A total of 645 FNACs were positive for malignancy, out of which there were 619 (96%) adenocarcinoma and 26 cases with unusual malignancies. These included adenosquamous carcinoma (8, 1.2%), squamous cell carcinoma (7, 1.1%), small cell neuroendocrine carcinoma (9, 1.3%), and one case each of undifferentiated carcinoma and Non Hodgkin lymphoma respectively. The unusual malignancies were confirmed on cell block immunocytochemistry. Conclusion Adenocarcinoma is most common type of gallbladder malignancy; however, other unusual types of carcinomas occur and in such cases, FNAC supplemented by cell block immunocytochemistry is required for an accurate diagnosis. Diagn. Cytopathol. 2016. © 2016 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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