| Autor: |
R.P. Enever, M. Shahjahan |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
International Journal of Pharmaceutics. 70:9-18 |
| ISSN: |
0378-5173 |
| DOI: |
10.1016/0378-5173(91)90158-k |
| Popis: |
Nonionic surfactants or polyethylene glycols were used to enhance the solubilities of nitrofurazone and ultraviolet light absorbers in aqueous solution. The ultraviolet light absorbers were representative of two structural classes, the substituted benzophenone (Uvinul D-50) and the substituted acrylonitriles (Uvinul N-35). The site of solubilization of drug and ultraviolet light absorbers in the surfactant micelles was investigated. The solubility results suggest that all three solubilizates are distributed between both the hydrophilic and hydrophobic regions of the micelles. Determination of the relative regions of solubilization in the micelle by comparing the changing Z values fits well with the data obtained from the solubility measurements for Uvinul D-50 and nitrofurazone but not for Uvinul N-35. The reason for the apparent anomalous Z value results with Uvinul-35 in surfactant solutions is not clear. The relatively low solubilities of the solubilizates in polyethylene glycol solutions, in particular Uvinul N-35, as compared to those in the surfactants emphasises the advantage of using the phenomenon of micelle formation to increase the solubility of these slightly water-soluble compounds. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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