Investigation of Dissolution Enhancement of Nifedipine by Deposition on Superdisintegrants

Autor:	Shu-Yang Yen, Ming-Tao Lee, Li-Chen Chen, Chun-Ren Chen
Rok vydání:	1997
Předmět:	Pharmacology Chromatography Chemistry Organic Chemistry Pharmaceutical Science Excipient Dosage form Relative significance Solvent Nifedipine Drug Discovery medicine Solvent effects Deposition (chemistry) Dissolution medicine.drug Nuclear chemistry
Zdroj:	Drug Development and Industrial Pharmacy. 23:313-317
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639049709149809
Popis:	In this study we aimed to investigate the dissolution enhancement of nifedipine by the solvent deposition technique using superdisintegrants including Ac-Di-Sol, Kollldon CL, and Explotab as excipients. The relative significance of action of solvent deposition (deposition of small drug particles on the excipient after solvent is evaporated) and action of superdislntegrant was investigated. The effect of solvent on dissolution of nifedipine in the solvent deposition system was also Investigated. Differential scanning calorlmetry (DSC) was used to study the interaction between nifedipine and superdisintegrants. Capsules and tablets of a physical mixture and a solvent deposition system of nifedipine were prepared. The dissolution rate of nifedipine of these capsules and tablets was studied. The results of this study show that solvent deposition system with lactose and super dlslntegrants in capsule and tablet dosage forms can significantly enhance dissolution rate of nifedipine. Both the action of su...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aa79359c0e13bae8408391c05fc2bd5c https://doi.org/10.3109/03639049709149809 Zobrazit plný text záznamu