Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of arg-gly-asp (RGD)
| Autor: | Naoyuki Nishikawa, Atsushi Orikasa, Mitsunori Ono, Jun Murata, Mitsuo Yoshikane, Hiroyuki Komazawa, Hideki Fujii, Isamu Itoh, Jiro Yamaguchi, Masayoshi Kojima, Ichiro Azuma, Ikuo Saiki |
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| Rok vydání: | 1996 |
| Předmět: |
chemistry.chemical_classification
endocrine system Chemistry Stereochemistry Organic Chemistry Clinical Biochemistry Lung metastasis Pharmaceutical Science Peptide medicine.disease Biochemistry Adenosine Metastasis Biological property Drug Discovery medicine Molecular Medicine Potency Retro inverso Molecular Biology Arg-Gly-Asp medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 6:2725-2728 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(96)00494-5 |
| Popis: | Partially modified retro and retro-inverso peptide analogs of Arg-Gly-Asp (RGD) were synthesized and examined their inhibitory effects of experimental lung metastasis of murine melanoma and adenosine 5′-diphosphate (ADP) induced platelet aggregation. The analogs showed efficient theraputic potency for the tumor metastasis but low inhibitory effect on ADP induced platelet aggregation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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