| Popis: |
The formation of hydrochlorothiazide inclusion complexes has been carried out to improve the physicochemical properties and increase the dissolution rate of hydrochlorothiazide. Inclusion complexes were made by co-grinding using ß cyclodextrin at a ratio of 1:1 mol, with variations in milling time, namely 30 minutes (F1), 1 hour (F2), and 2 hours (F3). The inclusion complexes formed were characterized by X-ray diffraction analysis, differential scanning calorimetry (DSC), Fourier transforms infrared (FT-IR), scanning electron microscopy, and dissolution tests. X-ray diffraction results showed a decrease in hydrochlorothiazide intensity, the DSC thermogram showed a decrease in endothermic peaks and enthalpy values, and FT-IR spectrum analysis showed that there was a chemical interaction between hydrochlorothiazide and ß-cyclodextrin. All characterization checks carried out met the requirements and confirmed an increase in the dissolution rate. The dissolution yield of hydrochlorothiazide was 41.711%, the physical mixture was 57.135%, the F1 inclusion complex was 59.52%, the F2 inclusion complex was 79.17%, and the F3 inclusion complex was 103.62%. This proves that the formation of inclusion complexes with the addition of ß-cyclodextrin can significantly increase the dissolution |
