N-Alkylation of Secondary Amine Tricyclic Antidepressants as a General Method for Their Quantitation by GC-MS-SIM Technique. Preparation of N-Ethyl Derivatives of Desimipramine, Nortriptyline, Protiptyline and Desmethyldoxepin
| Autor: | Robert O. Friedel, N. Narasimhachari |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
chemistry.chemical_classification
Chemical ionization Chromatography Chemistry Biochemistry (medical) Clinical Biochemistry Acetal Alkylation Biochemistry Analytical Chemistry chemistry.chemical_compound Reagent Electrochemistry medicine Dimethylformamide Organic chemistry Amine gas treating Nortriptyline Spectroscopy medicine.drug Tricyclic |
| Zdroj: | Analytical Letters. 12:77-88 |
| ISSN: | 1532-236X 0003-2719 |
| Popis: | A simple method for the preparation of N-ethyl derivatives of secondary amino tricyclic antidepressants is described, using dimethylformamide diethyl acetal as the alkylating reagent. The GC data and electron impact and chemical ionization mass spectra of N-ethyl derivatives are presented. The use of these derivatives in the quantitation of plasma levels of these drugs in clinical studies is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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