Bibenzyl Derivatives From Leaves of Dendrobium officinale
| Autor: | Chen Yunlong, Xiao Chuanyun, Chun-Hua Wu, Li Wenyan, Yan-Fei Xie, Wen-Zan Deng, Gang Ren |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
010405 organic chemistry Stereochemistry Plant Science General Medicine 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Dendrobium officinale Complementary and alternative medicine chemistry Drug Discovery Bibenzyl Dendrocandin B Cytotoxicity |
| Zdroj: | Natural Product Communications. 15:1934578X2090867 |
| ISSN: | 1555-9475 1934-578X |
| Popis: | Nine compounds were isolated from leaves of Dendrobium officinale, including 1 new bibenzyl derivative, denofficin (1), and 8 known structurally related compounds, dendrocandin B (2), dendrocandin U (3), 3,4-dihydroxy-5,4′-dimethoxy bibenzyl (4), moscatilin (5), 4,4′-dihydroxy-3,5-dimethoxy bibenzyl (6), ( S)-3,4,α-trihydroxy-5,4′-dimethoxy bibenzyl (7), gigantol (8), densiflorol A (9). The structures of these compounds were identified by spectroscopic methods. All isolated compounds were screened for their cytotoxicity against human cervical cancer cell line HeLa cells. Of them, compounds 1-3, 5, 6, and 8 were found to have the capabilities of proliferation inhibition against HeLa cells with half-maximal inhibitory concentration values ranging from 8.0 to 92.4 μM. |
| Databáze: | OpenAIRE |
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