Lesión hepatocelular inducida por alendronato

Autor:	S. J. Rodríguez Gómez, A. Pérez Villoria, J. Martínez Moreno, C.de la Serna Higuera, M. I. Martín Arribas, A. Betancourt González
Rok vydání:	2001
Předmět:	medicine.medical_specialty Hepatology medicine.diagnostic_test business.industry Osteoporosis Gastroenterology MEDLINE Routine laboratory medicine.disease Metabolic bone disease Internal medicine Female patient Medicine Elevated transaminases business Liver function tests Adverse effect
Zdroj:	Gastroenterología y Hepatología. 24:244-246
ISSN:	0210-5705
Popis:	Bisphosphonates are widely used in the treatment of metabolic bone disease. Bisphosphonate-induced hepatotoxicity is extremely infrequent. We present the case of a 76-year-old female patient with osteoporosis who was prescribed alendronate. A routine laboratory investigation carried out three months later revealed markedly elevated transaminase concentrations. Six weeks after withdrawal of treatment, laboratory parameters had returned to normal levels. We analyze this adverse reaction to alendronate as well as its possible pathogenic mechanisms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aa72a22be71fb7a39c84946a1730e93b https://doi.org/10.1016/s0210-5705(01)70164-1 Zobrazit plný text záznamu