LUNG PHOSPHOLIPIDS AND SURFACE TENSION CORRELATIONS IN INFANTS WITH AND WITHOUT HYALINE MEMBRANE DISEASE AND IN ADULTS

Autor:	George W. Brumley, W. Alan Hodson, Mary Ellen Avery
Rok vydání:	1967
Předmět:	Pediatrics Perinatology and Child Health
Zdroj:	Pediatrics. 40:13-19
ISSN:	1098-4275 0031-4005
DOI:	10.1542/peds.40.1.13
Popis:	Infants who have died with hyaline membrane disease have low concentrations of pulmonary phospholipids and reduced concentrations of saturated fatty acids at the alpha position of lung phosphatidyl choline. There is a highly significant correlation (p< .001) between levels below 12.6 mg of pulmonary phospholipid per gram wet weight lung and high minimum surface tension values of lung saline extracts. Infants without hyaline membrane disease have high concentrations of pulmonary phospholipids (22.3 mg per gram wet weight). Infants who recovered from HMD and died of other causes show values intermediate to those of HMD and non-HMD infants. The excess above the critical minimum noted here suggests a reservoir of pulmonary surfactant.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aa71d4dadaa443e9d380921f5700468c https://doi.org/10.1542/peds.40.1.13 Zobrazit plný text záznamu