Abstract 456: High Fat Diet-Induced Atherosclerosis-Driven Myocardial Infarction: Role of Cardiac Long Noncoding RNAs in Triiodo-L-Thyronine-Mediated Protection
| Autor: | Anna Domingo, Anthony Martin Gerdes, Jeanwoo Yoo, Clifford Costello, Viswanathan Rajagopalan, Olga V. Savinova, Youhua Zhang, Emily Schultz |
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| Rok vydání: | 2017 |
| Předmět: |
Cardioprotection
medicine.medical_specialty Physiology business.industry Coronary ligation Thyroid High fat diet medicine.disease chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Internal medicine Thyroid hormones Thyronine medicine Myocardial infarction Cardiology and Cardiovascular Medicine business Hormone |
| Zdroj: | Circulation Research. 121 |
| ISSN: | 1524-4571 0009-7330 |
| Popis: | Novel mechanisms associated with therapeutically safe thyroid hormone (TH) therapy are emerging. We have shown that oral triiodo-L-thyronine (T3) offers safe cardioprotection in coronary ligation myocardial infarction (MI), ligation ischemia-reperfusion injury, diabetic cardiomyopathy, etc. via restoration of gene expression. However, safe therapeutic effects following atherosclerosis-driven MI and role of long noncoding RNAs (lncRNAs) is unknown. We employed a mouse model of scavenger receptor B1 knockout with hypomorphic apolipoprotein E. Young adult heterozygote littermates served as controls and all mice received high fat (HF) diet for one month. Along with HF diet, a cohort of homozygotes (HypoE) received therapeutic dose of T3 (5.5 μg/kg/d) in drinking water ad libitum. In HypoE mice, Paigen HF diet induced interstitial fibrotic MI with severe hypertrophic (Heart wt./Body wt., HW/BW: control:4.6±0.14; HypoE:12.9±0.75; p2-fold; p |
| Databáze: | OpenAIRE |
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