Loading messenger RNAs onto ribosomes in human mitochondria: lessons learned from a bacterial toxin
| Autor: | Lukasz S. Borowski, Roman J. Szczesny |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbial toxins Cell Biology Mitochondrion Biology Biochemistry Genome Ribosome Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Organelle Mitochondrial ribosome Cellular model Molecular Biology Function (biology) |
| Zdroj: | The FEBS Journal. 288:434-436 |
| ISSN: | 1742-4658 1742-464X |
| Popis: | Mitochondria are peculiar organelles because their function depends on genetic information that is present in two genomes: nuclear and mitochondrial. The expression of mitochondrially encoded information requires dedicated machinery. Many efforts have been made to identify this machinery and describe its relevant mechanisms. Recently, Bruni et al. reported a cellular model that they established to investigate the pathway for loading messenger RNAs onto ribosomes in human mitochondria. Their study revealed a role for monosome formation in the stability of mitochondrial mRNAs. Comment on: https://doi.org/10.1111/febs.15342. |
| Databáze: | OpenAIRE |
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