| Autor: | Dusan Dobrota, Alexander A. Boldyrev, Ivan Tkáč, Milena Matejovičová, Serguei L. Stvolinsky, Maria Kukley |
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| Rok vydání: | 1999 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Antioxidant medicine.medical_treatment Ischemia Carnosine Endogeny Cell Biology General Medicine Pharmacology medicine.disease Brain ischemia Lipid peroxidation Cellular and Molecular Neuroscience chemistry.chemical_compound Biochemistry chemistry medicine Homeostasis |
| Zdroj: | Cellular and Molecular Neurobiology. 19:45-56 |
| ISSN: | 0272-4340 |
| Popis: | 1. The biological effects of carnosine, a natural hydrophilic neuropeptide, on the reactive oxygen species (ROS) pathological generation are reviewed. 2. We describe direct antioxidant action observed in the in vitro experiments. 3. Carnosine was found to effect metabolism indirectly. These effects are reflected in ROS turnover regulation and lipid peroxidation (LPO) processes. 4. During brain ischemia carnosine acts as a neuroprotector, contributing to better cerebral blood flow restoration, electroencephalography (EEG) normalization, decreased lactate accumulation, and enzymatic protection against ROS. 5. The data presented demonstrate that carnosine is a specific regulator of essential metabolic pathways in neurons supporting brain homeostasis under unfavorable conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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