Quantum dots based near-infrared fluorescent probe for the detection of PepT1 expression in colorectal cancer
| Autor: | Xiyuan Yu, Qi Niu, Qi Zhang, Dongsheng Yu, Weijie Hu, Qinling Yuan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oligopeptide
Chemistry General Physics and Astronomy Transporter 02 engineering and technology Tripeptide Conjugated system 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Fluorescence In vitro 0104 chemical sciences Quantum dot In vivo Biophysics Physical and Theoretical Chemistry 0210 nano-technology |
| Zdroj: | Chemical Physics Letters. 739:136977 |
| ISSN: | 0009-2614 |
| DOI: | 10.1016/j.cplett.2019.136977 |
| Popis: | The lysine-proline-valine tripeptide (KPV) can transport into colorectal cancer (CRC) cells via oligopeptide transporter 1 (PepT1) selectively. Here, we successfully designed a fluorescent probe for PepT1 receptor-targeted CRC imaging. This probe consisted of the CuInS2/ZnS (CIS/ZnS) quantum dots (QDs) conjugated with KPV (QD-PAAO-KPV), exhibiting excellent near-infrared emission characteristics. The in vitro and in vivo results showed that the QD-PAAO-KPV was specifically and efficiently internalized in the PepT1-overexpressing colorectal Caco-2 tumor. In addition, it demonstrated that the probe possessed good biological activities. Thus, this study revealed that the probe QD-PAAO-KPV presented desirable targeting ability, showing promising prospects in CRC detection. |
| Databáze: | OpenAIRE |
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