Sinus nodal reentry
| Autor: | Anthony N. Damato, Gerald M. Weisfogel, Karlen L. Paulay |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Quinidine
medicine.medical_specialty Infusion time business.industry Plasma levels Reentry Arrival time medicine.anatomical_structure Anesthesia Internal medicine cardiovascular system medicine Cardiology Cardiology and Cardiovascular Medicine NODAL business Beat (music) Sinus (anatomy) medicine.drug |
| Zdroj: | The American Journal of Cardiology. 33:617-622 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/0002-9149(74)90252-5 |
| Popis: | The recently developed experimental model for sinus nodal reentry was used to assess the effect of quinidine in 20 dogs. Sinus nodal reentry was demonstrated in 19 dogs and was abolished in all dogs when plasma levels of quinidine (average 4.8 mg/liter) were in the therapeutic range after an average infusion time of 7 minutes. Characteristically in 15 dogs, quinidine increased atrial refractoriness and slowed atrial conduction so that the arrival time of the atrial premature beat (A2) in the region of the sinus node fell outside the reentry zone and sinus nodal reentry was terminated. Conduction delay along the reentrant pathway preceded loss of sinus nodal reentry in 6 of these 15 dogs, thereby suggesting that quinidine-induced conduction delay and block along the reentrant pathway may be another mechanism for abolishing sinus nodal reentry. In the four remaining dogs in which sinus nodal reentry was abolished when the premature beat continued to fall within the reentry zone, the latter mechanism seems likely. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|