| Autor: | Hirokazu Wakebe, Etsuro Shoji, Nobuhiko Takahashi, Yutaka Kohgo, Toshikatsu Okumura, Mikio Kikuchi, Kenichi Imagawa |
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| Rok vydání: | 1998 |
| Předmět: |
Phenol red
medicine.medical_specialty biology Lipopolysaccharide Gastric emptying Physiology Spirillaceae Cell Gastroenterology Gastric motility Helicobacter pylori Pharmacology biology.organism_classification chemistry.chemical_compound medicine.anatomical_structure chemistry Internal medicine medicine Gastritis medicine.symptom |
| Zdroj: | Digestive Diseases and Sciences. 43:90-94 |
| ISSN: | 0163-2116 |
| DOI: | 10.1023/a:1018828105226 |
| Popis: | The present study was carried out to investigatethe possibility that lipopolysaccharide deprived fromHelicobacter pylori may alter gastric motility. Toaddress the question, we examined the effect of H. pylori lipopolysaccharide on gastricemptying in conscious rats. Gastric emptying wasevaluated by the phenol red method. Time-course anddose-related effects of intraperitoneal administrationof H. pylori lipopolysaccharide were investigated.Intraperitoneal injection of H. pylorilipopolysaccharide significantly suppressed gastricemptying of a liquid meal in a dose-dependent manner.The inhibitory action of H. pylori lipopolysaccharide wasobserved 2, 4, 8, or 12 hr after the injection. Theseresults suggest for the first time that H. pylorilipopolysaccharide may suppress gastric emptying in along-lasting fashion. It is also suggested that H. pylorimay influence gastric function through its cell wallstructure named lipopolysaccharide. |
| Databáze: | OpenAIRE |
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