Clinical Biochemistry of Gout
| Autor: | Mathias Müller |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
musculoskeletal diseases
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty business.industry nutritional and metabolic diseases medicine.disease Clinical biochemistry Gout chemistry.chemical_compound Endocrinology chemistry Hypoxanthine-guanine phosphoribosyltransferase Internal medicine Acute monoarticular arthritis medicine Uric acid Hyperuricemia Purine metabolism business Specific enzyme |
| Zdroj: | Clinical Chemistry ISBN: 9781461280651 |
| DOI: | 10.1007/978-1-4613-0753-2_24 |
| Popis: | In ancient documents of medicine Hippokrates, Seneca, Araetius and Galen described the distinctive picture of an acute monoarticular arthritis in the big toe, knee or hand which corresponds to our clinical description of gout today. In 1848 Garrod defined first the relationship between hyperuricemia and gout based on a congenital metabolic defect (1). However, the first specific enzyme defect responsible for a subtype of gout, hypoxanthine guanine phosphoribosyltransferase (HGPRT) deficiency, was discovered by Seegmiller and coworkers (2). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|