| Autor: |
Stephen R. Durham, Esther H. Steveling-Klein, Rachael C. Y. Li, Janice Layhadi, Suzanne M. Bal, Wytske Fokkens, Mohamed H. Shamji, Umit Murat Sahiner, Anke-Hilse Maitland-van der Zee, Oleksandra Fedina, Susanne J. H. Vijverberg, Madison M. Lenormand, Gemma Vilà-Nadal, Cornelis M. van Drunen, Balthasar A. Heesters, Korneliusz Golebski, Hergen Spits, Mongkol Lao-Araya |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| DOI: |
10.2139/ssrn.3611048 |
| Popis: |
SummaryIn this study, we addressed the role of IL-10-producing ILCs in controlling grass pollen allergy. IL-10+ ILCs are comprised in KLRG1+ILC2-lineage cells and absent on CRTH2+ ILC2 which lack KLRG1. We observed that ILC2s in healthy subjects and grass pollen allergic patients show differential gene expression profiles. A cross-sectional study demonstrates that IL-10-producing KLRG1+ ILC2s are strongly reduced in patients with grass pollen and house dust mite allergy when compared to healthy subjects and those who have received grass pollen subcutaneous immunotherapy treatment. In a prospective double-blind, placebo-controlled trial of grass pollen sublingual immunotherapy (SLIT), we observed that the capacity of ILC2 to produce IL-10 was restored in patients who received SLIT, but not patients receiving a placebo. Finally, we demonstrated that these IL-10-producing ILCs are functional and play a crucial role in restoring barrier function and tissue balance in allergic diseases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
