| Popis: |
It has previously been reported that feeding mice a marginal zinc (Zn) diet (5 μg Zn/g) during the last two-thirds of pregnancy results in long term deleterious effects on the offsprings' growth and immune function compared to control (100 μg Zn/g) offspring. However, recent results in our laboratory using a similar protocol have not been as dramatic as those previously reported. Since that study there has been modification of the diet employed. More importantly, virtually all commercial vendors now breed mouse colonies behind a pathogen free barrier. In the current study, we tested the hypothesis that differences in results were due to recent modifications in the diet, or due to a need for a more severe Zn deficiency to produce the previously reported effects. |
