Positive Relationship between L-type Amino Acid Transporter 1 Expression and Liver Metastasis in T3 Colorectal Cancer

Autor:	Takahiro Hobo, Mutsuko Omatsu, Shigeharu Hamatani, Koji Nogaki, Kaoru Kato, Toshiaki Kunimura, Toshio Morohoshi, Tomohiko Yoshida, Tetsuya Mikogami, Yuichi Takano
Rok vydání:	2011
Předmět:	Pathology medicine.medical_specialty Tumor size business.industry Colorectal cancer L-Type Amino Acid Transporter Lymph node metastasis medicine.disease Metastasis Cancer cell medicine Positive relationship Tumor location business
Zdroj:	The Showa University Journal of Medical Sciences. 23:145-151
ISSN:	2185-0968 0915-6380
DOI:	10.15369/sujms.23.145
Popis:	The aim of this retrospective study was to evaluate L-type amino acid transporter 1(LAT1)expression in colorectal cancer with invasion to the subserosal layer(T3) , its relationship with clinicopathological characteristics, and its potential metastatic signicance. LAT1 expression was measured by i mmunohistochemistry in tumors from 65 patients with primary colorectal carcinomas. LAT1 expression was deemed positive when more than 10% of the tumor cells showed distinct membranous immunoreactivity. Positive LAT1 expression was demonstrated in 29.2%(19 of 65)of primary tumors. LAT1 expression showed no signicant relationship with clinicopathological character- istics, such as age, gender, tumor location, tumor size, macroscopic/microscopic classication, or lymph node metastasis. However, LAT1 expression showed a positive relationship with liver metastasis(P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aa2880ab7d1d609f0f716098b3008000 https://doi.org/10.15369/sujms.23.145 Zobrazit plný text záznamu