Non-Aqueous Emulsions as Vehicles for Capsule Fillings

Autor:	Kurt H. Bauer, Betül Dortunç
Rok vydání:	1984
Předmět:	Pharmacology Aqueous solution Chromatography food.ingredient Chemistry Gelatin capsule Organic Chemistry Pharmaceutical Science Capsule Gelatin Gastrointestinal absorption food Drug Discovery PEG ratio Dissolution
Zdroj:	Drug Development and Industrial Pharmacy. 10:699-712
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639048409040778
Popis:	New vehicles were developed based on non-aqueous emulsions. They may be classified as progress or supplimentation to the actual respectively conventional filling masses for soft gelatin capsules, but also for liquid or semi-solid hard gelatin capsule filling techniques.IN-VITRO dissolution rate studies exhibit a clear superiority of PEG filling masses about oil-wax bases, which show extremely slow release rates.These experiencies may therefore open an interesting way of attaining better bioavailabilities in certain cases with soft gelatin capsules as well as with hard gelatin capsules.But in the following corresponding IN-VIVO tests, which are carried out as urine recoveries, the whole loss of superiority of the PEG compounds is impressingly shown. On the contrary the PEG bases exhibit IN-VIVO the lowest recoveries, while the non-aqueous emulsions at least those with the Riboflavin indicate a tendency towards a more favorable gastrointestinal absorption.
Databáze:	OpenAIRE
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