| Autor: |
La-or Chailurkit, Puavilai G, Noppawan Piaseu, S. Sae Tung, S. Chansirikarn, Suwannee Chanprasertyothin, Boonsong Ongphiphadhanakul, R. Rajatanavin, P. Payatikul |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
Clinical Endocrinology. 52:581-585 |
| ISSN: |
0300-0664 |
| DOI: |
10.1046/j.1365-2265.2000.00979.x |
| Popis: |
OBJECTIVE An oestrogen-receptor-α (ERα) gene polymorphism has been variably reported to be related to bone mass. To investigate whether this ERα gene polymorphism is associated with a functional difference, we assessed the response in bone mineral density (BMD) to oestrogen therapy in post-menopausal women in relation to ERα gene polymorphism. PATIENTS AND MEASUREMENTS Subjects consisted of 124 Thai post-menopausal women. Sixty-three of the women were less than 6 years post-menopausal and 61 were more than 10 years post-menopausal with vertebral or femoral osteoporosis as defined by BMD T-score less than − 2.5. Subjects were randomly allocated to receive 0.3 mg (n = 67) or 0.625 mg (n = 57) of conjugated equine oestrogen (CEE). All subjects also took 5 mg medroxyprogesterone acetate. Vertebral and femoral neck BMD were measured at baseline and 1 year after treatment. Data were expressed as mean ± SEM. Capital P represents the absence of the restriction site while lower-case p indicates the presence of the restriction site. RESULTS For subjects on 0.625 mg CEE, BMD at L2–4 increased significantly after 1 year in those with pp (n = 20) Pp (n = 29) and PP genotypes (n = 8) (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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