Streptococcal Related Glomerulonephritis
| Autor: | A. S. Markowitz, Raymond Clasen, Bernard D. Nidus, Herman Ainis |
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| Rok vydání: | 1967 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 98:161-170 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.98.1.161 |
| Popis: | Summary Glomerulonephritis has been produced in the rhesus monkey passively by the intravenous injection of sheep antiserum produced against a soluble fraction obtained from pooled human glomeruli (PGT HUGL). This antigen had previously been shown to be chemically similar to and immunologically cross-reactive with a soluble substance from type 12 nephritogenic streptococci. Glomerulonephritis was also produced in the monkey by active immunization with an alumprecipitate of PGT HUGL as the immunogen. Immunofluorescence evidence was presented to indicate that the sheep and monkey γ-globulin localized in the glomeruli in the passively produced disease, while autologous γ-globulin was found in the actively induced disease. No immunofluorescence evidence could be obtained to indicate the presence of the injected material in the glomeruli of the actively immunized animals. The concept is submitted that in the latter group tolerance was broken and that the globulin which localized was antibody-reactive with a determinant grouping on the monkey glomerular basement membrane. |
| Databáze: | OpenAIRE |
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