Diels–Alder reactions with pyridine o-quinodimethanes generated from pyridine sulfolenes

Autor:	Georges J. Hoornaert, Ilse A. Vogels, Steven L. Cappelle, Frans Compernolle, Suzanne Toppet, Tom C Govaerts
Rok vydání:	2002
Předmět:	chemistry.chemical_compound Chemistry Organic Chemistry Drug Discovery Pyridine Diels alder Organic chemistry Extrusion Biochemistry Sulfur dioxide Adduct
Zdroj:	Tetrahedron. 58:3655-3666
ISSN:	0040-4020
Popis:	An efficient route has been developed for the synthesis of polysubstituted 6,6-dioxo-6,7-dihydrothieno[3,4- b ]pyridines 3 , which serve as excellent precursors for generation of the corresponding pyridine o -quinodimethanes. Following thermal extrusion of sulfur dioxide, these reactive species can be trapped in situ with electron rich, neutral, and electron deficient dienophiles. The regio and stereochemical structure of the resulting adducts was determined by NMR analysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aa0c07da0ad45f9aa4d919049ae81515 https://doi.org/10.1016/s0040-4020(02)00348-4 Zobrazit plný text záznamu Full Text from ScienceDirect