Molecular Genetic and Functional Analysis of the Genome of Bacteria Bacillus velezensis BIM B-439D
| Autor: | A. V. Berezhnaya, O. V. Evdokimova, L. N. Valentovich, E. I. Kolomiyets, N. V. Sverchkova, M. A. Titok |
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| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0301 basic medicine Siderophore food and beverages Biology Bacillibactin biology.organism_classification 01 natural sciences Applied Microbiology and Biotechnology Biochemistry Microbiology 03 medical and health sciences Polyketide Bacillomycin chemistry.chemical_compound 030104 developmental biology chemistry Bacteriocin 010608 biotechnology Surfactin Bacteria Botrytis cinerea |
| Zdroj: | Applied Biochemistry and Microbiology. 55:386-396 |
| ISSN: | 1608-3024 0003-6838 |
| DOI: | 10.1134/s0003683819040033 |
| Popis: | Whole-genome sequencing of bacteria Bacillus velezensis BIM B-439D has revealed that its genome is represented by a single circular chromosome 3 978 954 bp in size and contains 3969 predicted genes. Chromosome has 10 conserved loci that determine the production of antimicrobial compounds of varying chemical nature, namely lipopeptides (surfactin, bacillomycin, fengycin), polyketides (bacillaene, difficidin/oxydifficidin, macrolactin), bacillibactin siderophore, dipeptide bacilysin, a protein/polyketide of uncertain composition, and amylocyclicin bacteriocin. Mutants with impaired surfactin synthesis have been obtained by direct mutagenesis; they were characterized by an increased production of bacillomycin and fengycin. The obtained mutants demonstrated high antimicrobial activity towards a number of bacterial and fungal pathogens (Penicillium expansum, Alternaria tenuis, Botrytis cinerea,Bipolaris sorokiniana), but they inhibited the growth of the Fusarium genus fungi to a lesser degree. |
| Databáze: | OpenAIRE |
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