PAPARAN ORGANOFOSFAT KRONIK SEBAGAI FAKTOR RISIKO GANGGUAN KOGNITIF BERDASARKAN KADAR PHOSPHORYLATED TAU SERUM

Autor:	Anak Agung Ayu Putri Laksmidew, ni luh Putu Dirasandhi Semedi Putri, I Made Oka Adnyana
Rok vydání:	2020
Předmět:	Chronic exposure chemistry.chemical_compound medicine.medical_specialty chemistry business.industry Internal medicine Organophosphate medicine business Gastroenterology
Zdroj:	Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia. 37
ISSN:	2502-3748 0216-6402
DOI:	10.52386/neurona.v37i2.114
Popis:	CHRONIC ORGANOPHOSPHATE EXPOSURE AS A RISK FACTOR OF NEUROCOGNITIVE IMPAIRMENT THROUGH HIGH LEVEL OF PHOSPHORYLATED TAU SERUMABSTRACT Introduction: Chronic organophosphate exposure is predicted related to decreased of neurocognitive function, but the mechanism is still unclear. One possible mechanism is abnormal tau protein metabolism as measured in the serum. Aims: To measure the role of chronic organophosphate exposure causing neurocognitive impairment through high serum levels of phosphorylated tau protein (p-tau).Methods: This case control study was conducted in Penarukan Village, Tabanan, Balifrom July 2018 to January 2019. This study involved farmers aged 40-60 years who used organophosphates pesticide for at least the last 2 years and did not wear any personal protective equipment during pesticide use. Neurocognitive function was evaluated using Mini Cog Test. The level of p-tau was measured by taking a 2 mililiters of blood sample and analyzed using enzyme-linked immunosorbent assay (ELISA) method.Results: Sixty six(case = 33; control = 33) subjects were enrolled.Exposure to pesticides for ≥10 years had a higher risk for neurocognitive impairment than
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a9f3548ad328dc87f444963b724b9ab9 https://doi.org/10.52386/neurona.v37i2.114 Zobrazit plný text záznamu