Value of whole-liver apparent diffusion coefficient histogram analysis for quantification of liver fibrosis stages
| Autor: | Caixia Fu, Xin-Xing Hu, Xu Yan, Mengsu Zeng, Robert Grimm, Zhao-Xia Yang, Sheng-Xiang Rao |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Chinese Journal of Academic Radiology. 1:6-12 |
| ISSN: | 2520-8993 2520-8985 |
| Popis: | To explore whether volumetric acquisition of histogram analysis of apparent diffusion coefficient (ADC) maps could quantify liver fibrosis stages. 84 patients underwent MRI exams including DWI before surgery or liver biopsy were included. Histogram analysis of whole liver ADC maps were performed and parameters including ADC mean, ADC median, ADC skewness, ADC kurtosis, ADC standard deviation (SD), ADC 5th, 10th, 25th, 75th, 90th and 95th percentiles were calculated. The correlations between different histopathologic grades and histogram analysis parameters were determined. For the significant parameters, receiver operating characteristics (ROC) analyses were further established to evaluate the potential diagnostic performance for differentiating liver fibrosis stages. The ADC mean and ADC median, ADC SD, ADC5th, 10th, 25th, 75th, 90th and 95th percentile were significantly lower with the increasing grade of liver fibrosis (rho: from − 0.580 to − 0.230). ADC skewness and ADC kurtosis were significantly higher with the increasing grade of liver fibrosis (rho: 0.243, 0.347, respectively). Areas under the ROC curve (AUC) of ADC mean and ADC 75th percentile for identification liver fibrosis (F1–F4), moderate to advanced liver fibrosis (F2–F4), advanced liver fibrosis (F3–F4), cirrhosis (F4) were 0.87, 0.83, 0.82, 0.76 and 0.88, 0.82, 0.80, 0.74, respectively. Histogram analysis of volumetric acquisition of liver ADC maps has a potential value for quantifying liver fibrosis grades. |
| Databáze: | OpenAIRE |
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