EFEKTIVITAS DOSIS KARBON TETRAKLORIDA (CCl4) TERHADAP TIKUS (Rattus norvegicus L.) SEBAGAI HEWAN MODEL FIBROSIS HATI

Autor:	Hajar Indra Wardhana, Fahri Fahrudin, Fathin Hamida, Sri Ningsih, Dinda Rama Haribowo
Rok vydání:	2020
Předmět:	medicine.medical_specialty food.ingredient business.industry Liver fibrosis Coconut oil CCL4 General Medicine General Chemistry medicine.disease digestive system Gastroenterology Animal model food Fibrosis Internal medicine Liver enzyme Male rats Medicine Liver damage business
Zdroj:	BERITA BIOLOGI. 19
ISSN:	2337-8751 0126-1754
DOI:	10.14203/beritabiologi.v19i3b.3961
Popis:	Liver damage can produce fibrosis condition both acute and chronic. Development of liver fibrosis in animal models is valuable information in order to gain new entities for treatment. The aim of this study is to get an optimal condition of CCl4 induction for achieving animal models of liver fibrosis. CCl4 diluted in coconut oil was administrated orally for 6 consecutive weeks. Total 25 male rats were divided into 5 treatment groups, namely, P1 was a normal group (without CCl4). P2 (CCl4 40%), 1 ml/kg bw 3 times a week. P3 (CCl4 40%), 0.5 ml/kg bw 3 times a week, P4 (CCl4 10%) 1 ml/kg bw 3 times a week, and P5 (CCl4 10%) 1 ml/kg bw twice a week. The analyzed parameters were the activity of liver enzymes, macro and microscopic liver damage, and the percentage of rat deaths. The results of this study indicated an increase in liver enzymes in all treatments which was higher than P1 (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a9ded9900fa6e00f61b668509114ee84 https://doi.org/10.14203/beritabiologi.v19i3b.3961 Zobrazit plný text záznamu