RELATIONSHIP BETWEEN ANGIOTENSIN-CONVERTING ENZYME GENE POLYMORPHISM AND CHRONIC RENAL TRANSPLANT DYSFUNCTION
| Autor: | F.N. Ozdemir, Hasibe Verdi, Turan Colak, Ali Akcay, Siren Sezer, Zubeyde Arat, Fatma Belgin Ataç, Mehmet Haberal, M Terzioğlu |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Proteinuria biology business.industry Immunology Renal function Angiotensin-converting enzyme General Medicine Human leukocyte antigen medicine.disease Biochemistry Gastroenterology Transplantation Internal medicine Genotype Genetics biology.protein medicine Immunology and Allergy Gene polymorphism medicine.symptom business Kidney disease |
| Zdroj: | Tissue Antigens. 60:554-554 |
| ISSN: | 0001-2815 |
| DOI: | 10.1034/j.1399-0039.2002.00013.x |
| Popis: | Chronic allograft dysfunction (CAD) is a complex phenomenon caused by underlying kidney disease and superimposed environmental and genetic factors. We investigated the relationship between polymorphism in the gene encoding for angiotensin-converting enzyme (ACE) and CAD in renal transplant recipients. The study included 125 patients who underwent transplantation over a 5-year period. The following information was collected for each case: date of transplantation, age and sex of donor and recipient, donor type, cold ischemia time, number of HLA mismatches, number of acute-rejection episodes, and laboratory findings at discharge from hospital and annual rechecks. Blood pressure was measured at yearly intervals throughout the follow up. DNA isolated from mononuclear cells in peripheral blood was used as a template for amplification of insertion/deletion (I/D) polymorphism in the ACE gene by polymerase chain reaction. The proportions of patients with the different genotypes were DD=54.4%, ID=33.6%, and II=12%. Chronic allograft dysfunction was detected in 36 (52.9%) of the recipients with DD genotype and 15 (26.3%) of those with ID or II genotypes (P |
| Databáze: | OpenAIRE |
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