Expanding the scope of silane-mediated hydrodehalogenation reactions

Autor:	Gary M. Noonan, Timothy W. Gorman, Barry R. Hayter, Andrew D. Campbell, Benjamin E. Partridge, Gill M. Lamont
Rok vydání:	2013
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Scope (project management) chemistry Carboxylic acid Aryl Organic Chemistry Drug Discovery Substrate (chemistry) Biochemistry Combinatorial chemistry Silane
Zdroj:	Tetrahedron Letters. 54:4518-4521
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2013.06.063
Popis:	A palladium-catalysed, silane-mediated hydrodehalogenation (HDH) reaction with increased substrate scope has been developed. Whereas previous attempts to reduce carboxylic acid or phenol-containing aryl halides using silane-based HDH conditions failed, the current protocol allows efficient access to the reduced products. Chemoselective HDH in the presence of sensitive functional groups is also presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a9d2cb16114f14063c582002722e77b0 https://doi.org/10.1016/j.tetlet.2013.06.063 Zobrazit plný text záznamu Full Text from ScienceDirect