A new C2-symmetric chiral diphosphine ligand: palladium-catalyzed enantioselective allylic alkylation of cycloalkenyl substrate

Autor:	Mie Misawa, Akihito Saitoh, Toshiaki Morimoto
Rok vydání:	1999
Předmět:	Allylic rearrangement Chemistry Ligand Stereochemistry Organic Chemistry Enantioselective synthesis chemistry.chemical_element Asymmetric induction Catalysis Inorganic Chemistry Amidine chemistry.chemical_compound Tsuji–Trost reaction Physical and Theoretical Chemistry Palladium
Zdroj:	Tetrahedron: Asymmetry. 10:1025-1028
ISSN:	0957-4166
Popis:	A novel C2-symmetric chiral diphosphine ligand 1 was developed using (2S)-2-amino-1-(diphenylphosphino)-3-methylbutane 2 which was derived from l -valine as in the previous work for the chiral amidine ligand, VALAP. Ligand 1 demonstrated extremely high levels of asymmetric induction, over 99% ee in palladium-catalyzed allylic alkylations of 2-cyclohexen-1-yl pivalate 5.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a9cd851e3b9994a2941a9b379c3880de https://doi.org/10.1016/s0957-4166(99)00100-7 Zobrazit plný text záznamu Full Text from ScienceDirect