ChemInform Abstract: Synthesis of (2S,5S)-5-Fluoromethylornithine; a Potent Inhibitor of Ornithine Aminotransferase

Autor:	Pascale Zimmermann, J. B. Ducep, K. Jund, M. Schleimer, B. Lesur, B. Heintzelmann
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Hydrolysis chemistry Resolution (mass spectrometry) Stereochemistry Ornithine aminotransferase Diastereomer Benzylpenicillinase General Medicine Enantiomer Amino acid
Zdroj:	ChemInform. 28
ISSN:	0931-7597
DOI:	10.1002/chin.199722212
Popis:	Only one of the four enantiomers of 5-fluoromethylornithine 1 was an irreversible inhibitor of ornithine aminotransferase. The active enantiomer 1a was synthesized from diaminoadipic acid 2 with a chemical diastereomeric separation and an enantiomeric resolution by hydrolysis of a phenylacetamide with benzylpenicillinase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a9afde3ab0a1f8be85b5a79ce5c9cf06 https://doi.org/10.1002/chin.199722212 Zobrazit plný text záznamu Plný text