| Autor: |
Nadia Vandenberghe, Andoni Echaniz-Laguna, Pierre-François Pradat, Annie Verschueren, J.-P. Camdessanché, Philippe Corcia, Pascal Cintas, J. Gonzalez, Guillaume Nicolas, L. Carluer, Véronique Danel-Brunaud |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Revue Neurologique. 165:532-541 |
| ISSN: |
0035-3787 |
| Popis: |
This paper from a group of French experts in amyotrophic lateral sclerosis (ALS) presents an update of recent advances in fundamental, epidemiological and clinical research in ALS. Recent development in the pathogenesis of ALS suggests that motor neuron degeneration is a multifactorial and noncell autonomous process. Research has been advanced through the identification of the TAR-DNA-binding protein (TDP-43) as a common neuropathological marker of ALS and frontotemporal lobar degeneration with ubiquitin-positive inclusions. Recently, mutations in the TDP-43 gene have been described in individuals with familial and sporadic ALS. Fundamental research in ALS is expected to lead to the disclosure of new diagnostic markers and therapeutic targets. A small trial has suggested that lithium carbonate may slow ALS progression but larger trials will be needed to confirm these results. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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