Concomitant chemoradiation in locally advanced head and neck squamous cell carcinoma: A literature-based meta-analysis on the platinum concomitant chemotherapy

Autor:	D. Garavaglia, Adriano Paccagnella, Irene Floriani, Maria Grazia Ghi
Rok vydání:	2011
Předmět:	Oncology Cisplatin Cancer Research medicine.medical_specialty business.industry Standard treatment Hazard ratio medicine.disease Head and neck squamous-cell carcinoma Carboplatin chemistry.chemical_compound Regimen chemistry Concomitant Internal medicine medicine Mucositis business medicine.drug
Zdroj:	Journal of Clinical Oncology. 29:5534-5534
ISSN:	1527-7755 0732-183X
Popis:	5534 Background: Concomitant platinum-based chemoradiation (CRT) is the standard treatment for locally advanced squamous cell carcinoma. As no consensus regarding the optimal concomitant platinum-based regimen exist, a literature based meta-analysis was performed. Methods: Randomized trials comparing radiation alone (RT) vs concomitant platinum-based CRT were identified by electronic search. The main endpoints were to compare the efficacy with regards to cisplatin total dose and platinum compounds (cisplatin vs carboplatin). Hazard ratios (HRs) and their 95% confidence intervals (CIs) were used to measure the relative effect of treatments on overall survival (OS). Heterogeneity among trials wastested by Chi-Square test and I2index. The incidence of Grade (G) 3-4 mucositis was also analyzed by means of a Chi-Square test. Results: Fifteen trials were identified and 2502 patients were available for the analysis. No difference in OS was observed between cisplatin high dose (300mg/sqm) (HR 0.59, 95% CI 0.46-0....
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a99ce3696b0351443acef72b96b0f8b2 https://doi.org/10.1200/jco.2011.29.15_suppl.5534 Zobrazit plný text záznamu