Practical Large-Scale Preparation of (±)-2-exo-Norbornyl Carboxylic Acid and Its Improved Isolation As the Sodium Salt

Autor:	Thomas Storz, Charles C. Wu, Jianxin Gu, Frederick Vyverberg, Karen Sutherland, Varsolona Richard J
Rok vydání:	2011
Předmět:	chemistry.chemical_classification chemistry Carboxylic acid Organic Chemistry Organic chemistry Physical and Theoretical Chemistry 2-Norbornyl cation humanities Hydroformylation Sodium salt
Zdroj:	Organic Process Research & Development. 15:942-945
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op100284a
Popis:	A practical, robust, and high-yielding three-step−one-pot procedure for the diastereoselective synthesis of (±)-2-exo-norbornyl carboxylic acid starting from norbornylene has been found and demonstrated on multikilogram scale, setting a new benchmark for low-pressure hydroformylation of cyclic, bridged olefins. The newly found, nonhygroscopic crystalline sodium salt of this acid provides a practical isolation point.
Databáze:	OpenAIRE
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