Robinson Cytologic Grading of Invasive Ductal Breast Carcinoma
| Autor: | Antonio Robles-Frías, Diego Martínez-Parra, Ricardo González-Cámpora, Ana Fernández-Palacín, Otal-Salaverri C, Teresa Vázquez-Cerezuela, María José Robles-Frías |
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| Rok vydání: | 2005 |
| Předmět: |
Pathology
medicine.medical_specialty Histology medicine.diagnostic_test business.industry medicine.medical_treatment Not Otherwise Specified Anatomical pathology General Medicine medicine.disease Pathology and Forensic Medicine Metastasis Biopsy medicine Carcinoma Breast carcinoma business Grading (tumors) Neoadjuvant therapy |
| Zdroj: | Acta Cytologica. 49:149-153 |
| ISSN: | 1938-2650 0001-5547 |
| DOI: | 10.1159/000326123 |
| Popis: | OBJECTIVE To evaluate the importance of cytologic grading of breast carcinoma and its association with histologic grading and the existence of axillary lymph node metastasis. STUDY DESIGN Aspirates and surgical samples from 100 patients with invasive ductal breast carcinoma not otherwise specified were studied. In 50 patients, > or = 1 metastatic nodes were identified. The cytologic grade was evaluated using the Robinson method and the histologic grade using the Elston modification of the Bloom-Richardson method. A study was undertaken to establish the association between histologic and cytologic grades and to compare the various parameters used to evaluate cytologic grade with the presence of axillary node metastasis. RESULTS A statistically significant association was observed between cytologic and histologic grades (p < 0.0005) and between cytologic grade and presence of axillary metastasis (p < 0.0005). Similarly, cell dissociation (p < 0.0005), cell uniformity (p = 0.0010) and the appearance of nuclear margins (p < 0.0005) all displayed a positive correlation with regional metastasis. CONCLUSION Cytologic grade may provide relevant information on the aggressiveness of invasive ductal breast carcinoma and could be a useful parameter to take into consideration when selecting neoadjuvant therapy. |
| Databáze: | OpenAIRE |
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