Identification, development, synthesis and evaluation of boron-containing nucleosides for neutron capture therapy
| Autor: | A. K. M. Anisuzzaman, A. J. Lunato, Feng-Guang Rong, Albert H. Soloway, Beverly A. Barnum, David H. Ives, C. D. Barth, Jin-Cong Zhuo, Rolf F. Barth |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
inorganic chemicals
chemistry.chemical_classification Kinase Organic Chemistry chemistry.chemical_element Biochemistry Combinatorial chemistry In vitro Inorganic Chemistry Neutron capture chemistry Thymidine kinase Boron containing Materials Chemistry Malignant cells Nucleotide Physical and Theoretical Chemistry Boron |
| Zdroj: | Journal of Organometallic Chemistry. 581:150-155 |
| ISSN: | 0022-328X |
| Popis: | The development of boron compounds with the capacity for selectively targeting tumor cells would offer the potential for specifically destroying such cells using the capture reaction of the nonradioactive 10 B nuclide and thermal neutrons. The key problem is the development of compounds with the ability to discriminate between tumor cells and contiguous normal cells and to concentrate in the former at suitable concentration levels. One category of agents that has been explored is boron-containing nucleosides. Such recent structures have been biochemically converted in vitro to their corresponding nucleotides by the action of human thymidine kinase. These studies have attempted to correlate a compound’s physiochemical properties with its biochemical attributes. Since only a fraction of cells are undergoing replication at any one time, requiring the need for nucleic acid precursors, such boron compounds must be only one component of a cocktail of agents that are targeting malignant cells. This presentation is selective, focusing on those boron-containing nucleosides that have been designed for studies with kinases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect