Claudin rather than occludin is essential for differentiation in rat incisor odontoblasts

Autor:	Takashi Muramatsu, H. Ogiuchi, M Hoshino, Miwako Matsuki, Masaki Shimono, Sadamitsu Hashimoto
Rok vydání:	2008
Předmět:	Pathology medicine.medical_specialty Tight junction Chemistry Cellular differentiation Immunoelectron microscopy Occludin Cell biology Blot Odontoblast stomatognathic system Otorhinolaryngology Dentinogenesis medicine Claudin General Dentistry
Zdroj:	Oral Diseases. 14:606-612
ISSN:	1601-0825 1354-523X
Popis:	Many morphological and developmental studies have demonstrated the characteristics of tight junctions (TJs) between odontoblasts. However, detailed localization of TJ-associated proteins in odontoblasts and their functions has not yet been clarified. To elucidate the relationship between the establishment of TJ structures and the differentiation of odontoblasts during early dentinogenesis, we studied the expression and localization of constituent proteins of TJs (claudin-1, occludin, ZO-1 and ZO-2) between odontoblasts in rat lower incisors using Western blotting, immunofluorescence and immunoelectron microscopy. When the expression of claudin-1 increases at the distal portion of mature odontoblasts, the TJs form complex networks of strands, and odontoblasts differentiated by developing distal membrane domains and by secreting specific molecules for mineralization. We conclude that the TJs of odontoblasts may play an important role in the differentiation of odontoblasts in rat lower incisors during early dentinogenesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a97f0977bc1ccb18edc2a78f958aafa8 https://doi.org/10.1111/j.1601-0825.2007.01427.x Zobrazit plný text záznamu Plný text